منابع مشابه
Adjuvant Systemic Therapy of Breast Cancer
patients younger than 50 years of 12%, and of endocrine therapy of 12%, as well as for patients older than 50 years with endocrine-responsive disease, with regard to disease-free survival with a follow-up time of 15 years [1]. In HER2/neu-overexpressing breast cancer there is an even larger benefit for patients treated with adjuvant chemotherapy in combination with the antibody trastuzumab (app...
متن کاملAdjuvant systemic therapy for breast cancer.
The first procedure in primary breast cancer is usually the surgical excision of the tumor. However, a medical therapy is necessary in almost all patients to treat the systemic component of the disease. Which medical approach is recommended depends on the biology of the tumor itself. Endocrine-responsive tumors must be treated by an endocrine therapy according to their menopausal status. In HER...
متن کاملTime-Varying Effects of Breast Cancer Adjuvant Systemic Therapy.
BACKGROUND The benefits of breast cancer adjuvant systemic treatments are generally assumed to be proportional (or constant) over time, but limited data suggest that some treatment effects may vary with time. We therefore systematically assessed the proportional hazards assumption across all 19 breast cancer adjuvant systemic therapy trials in the National Surgical Adjuvant Breast and Bowel Pro...
متن کاملAdjuvant systemic therapy for early breast cancer: progress and controversies.
The diagnosis and management of breast cancer have changed considerably over the past 4 decades. The introduction of adjuvant endocrine therapy (ovarian ablation) and adjuvant chemotherapy in the 1960s was a paradigm-changing event, based on improved understanding of the natural history of human breast cancer and the increased realization that micrometastases were in existence in most patients ...
متن کاملAdjuvant systemic therapy in breast cancer: quo vadis?
The premise that breast cancer (BC) has a tendency toward early systemic dissemination, together with empirical findings showing that drugs given after breast tumor surgery improve outcome, led to the development of systemic adjuvant therapy. This strategy, which started more than 50 years ago, revolutionized BC treatment and improved patient outcome in a substantial way. However, in recent yea...
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ژورنال
عنوان ژورنال: Breast Care
سال: 2011
ISSN: 1661-3805,1661-3791
DOI: 10.1159/000329336